The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate
Jan 01, 2012 • By P Gergely1, B Nuesslein-Hildesheim1, D Guerini1, V Brinkmann1, M Traebert1, C Bruns1, S Pan2, NS Gray2, K Hinterding1, NG Cooke1, A Groenewegen1, A Vitaliti1, T Sing3, O Luttringer3, J Yang1, A Gardin1, N Wang1, WJ Crumb Jr4, M Saltzman5, M Rosenberg5 and E Wallström3
Background And Purpose BAF312 is a next-generation sphingosine 1-phosphate (S1P) receptor modulator, selective for S1P1 and S1P5 receptors. S1P1 receptors are essential for lymphocyte egress from lymph nodes and a drug target in immune-mediated diseases. Here, we have characterized the…
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