Crumb, William J., Jr., John D. Pigott, and Craig W. Clarkson. Comparison of Ito in young and adult human atria myocytes: evidence for developmental changes. Am. J. Physiol. 268 (Heart Circ. physiol. 37): Hl335-H1342, 1995.-In an effort to understand the ionic basis for the developmental changes…
Read moreThe International Council on Harmonization (ICH) S7B and E14 regulatory guidelines are sensitive but not specific for predicting which drugs are pro-arrhythmic. In response, the Comprehensive In Vitro Proarrhythmia Assay (CiPA) was proposed that integrates multi-ion channel pharmacology data in…
Read moreAbstract Clinical studies have suggested that quinidine is less effective when used for the treatment of atrial arrhythmias in pediatric patients compared with its clinical effectiveness in the adult patient population. Age-related changes in the cardiac actions of quinidine on action potential…
Read moreAbstract Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for assessment of drug-induced arrhythmias and are being considered for use under the comprehensive in vitro proarrhythmia assay (CiPA). We studied the effects of 26 drugs and 3 drug combinations on 2 commercially…
Read moreAbstract Introduction: The Comprehensive in vitro Proarrhythmia Assay (CiPA) is intended to address the misidentification of drug-associated torsade de pointes risk based solely on hERG and QT data. This newparadigmwill consist of four interrelated components, one of which is a panel consisting of…
Read more